Lincoln J. McBride
Papers
1
Total Citations
6
H-Index
1
About
Lincoln J. McBride is a pioneering figure in molecular diagnostics and automated genomic analysis. His foundational work in the early 1990s introduced a fully integrated system for the automation of specific human gene detection, combining a novel solution-phase chemical procedure functionally equivalent to Southern blotting with a real-time fluorescence gel scanner. This prototype liquid-handling instrument and detection method laid critical groundwork for high-throughput, non-radioactive DNA analysis, directly influencing the development of modern clinical genotyping and automated molecular testing platforms. While his most-cited paper (6 citations) reflects a niche but seminal contribution, McBride’s true impact lies in his role as an early architect of automation in molecular biology—bridging the gap between manual benchwork and scalable, instrument-driven diagnostics. His work remains a reference point for researchers developing integrated systems for genetic analysis, particularly in the transition from radioactive to fluorescent detection. McBride’s contributions exemplify how engineering and chemistry converge to transform human gene detection, enabling faster, safer, and more reproducible workflows that underpin today’s genomic medicine.
Research Focus
Key Achievements
Top Papers
- 1Automation of specific human gene detection.6 citations · 1990