Lina Schiffer
Papers
1
Total Citations
35
H-Index
1
About
Lina Schiffer is a leading researcher in the field of biocatalysis and steroid biochemistry, with a particular focus on the engineering of cytochrome P450 enzymes for pharmaceutical applications. Her most notable contribution is the development of a recombinant *E. coli* biocatalyst expressing human CYP11B1, which enables the selective one-step 11β-hydroxylation of 11-deoxycortisol to produce cortisol—a process of immense therapeutic relevance given cortisol’s role as a key anti-inflammatory and immunosuppressive drug. This work, published in 2015 and garnering 35 citations, demonstrated not only the feasibility of using a bacterial host for complex human steroid transformations but also optimized the system toward preparative-scale production, bridging the gap between laboratory discovery and industrial application. Schiffer’s research sits at the intersection of synthetic biology, enzyme engineering, and green chemistry, offering a sustainable alternative to traditional multi-step chemical synthesis. Her achievements highlight a powerful strategy for producing high-value steroid hormones efficiently and selectively, marking her as a significant contributor to the advancement of biocatalytic manufacturing in the pharmaceutical industry.
Research Focus
Key Achievements
Top Papers
- 1