Anna Hobler
Papers
1
Total Citations
35
H-Index
1
About
Anna Hobler is a leading figure in the field of biotransformation and synthetic biology, with a primary focus on the development of recombinant microbial biocatalysts for the production of steroid hormones. Her most significant contribution is the creation of a groundbreaking *E. coli* biocatalyst that expresses human CYP11B1, enabling the selective one-step biosynthesis of cortisol from 11-deoxycortisol. This work, published in 2015 and garnering 35 citations, represents a major advance in industrial biotechnology by replacing complex, multi-step chemical syntheses with a cleaner, more efficient enzymatic process. Hobler’s research directly addresses the commercial need for sustainable production of therapeutic steroids, notably cortisol, a critical anti-inflammatory and immunosuppressive drug. By optimizing this system toward a preparative scale, she has laid the foundation for scalable, cost-effective manufacturing of high-value pharmaceuticals, showcasing the powerful intersection of enzyme engineering and green chemistry.
Research Focus
Key Achievements
Top Papers
- 1