Liam A. McDonnell

Fondazione Pisa, Leiden University Medical Center

Papers

Total Citations

H-Index

About

Liam A. McDonnell is a leading figure in mass spectrometry-based proteomics and imaging, with a focus on advancing high-sensitivity, high-throughput methodologies for biomedical research. His key research areas include quantitative microproteomics, automated sample preparation, and imaging mass spectrometry (IMS), where he has pioneered techniques to analyze minute tissue samples with unprecedented precision. One of his major contributions is the development of a set of novel automated quantitative microproteomics protocols for small sample amounts, demonstrated in a 2016 study (41 citations) that assessed an automated device with disposable microcolumns for label-free and isobaric labeling approaches, enabling robust analysis of kidney tissue substructures. This work addresses critical challenges in handling mass-limited samples, opening new avenues for spatial proteomics. Additionally, his 2009 paper on automated imaging MS (34 citations) advanced high-throughput IMS, streamlining the acquisition of molecular images from tissue sections. McDonnell’s impact is evident in his citation record and the practical applications of his methods in clinical and biological contexts. His achievements include driving innovation in automated workflows, making him a key contributor to the evolution of proteomics and imaging technologies for translational research.