Leonie Wyffels

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About

Leonie Wyffels is a leading radiochemist and molecular imaging researcher whose work bridges polymer chemistry and nuclear medicine. Her primary research focuses on the development and in vivo evaluation of novel radiolabeled polymers for positron emission tomography (PET) imaging, with a particular emphasis on optimizing pharmacokinetics and biodistribution. Wyffels’ most cited work, "In vivo imaging of 89Zr-labeled poly(2-ethyl-2-oxazoline)s and poly(ethylene glycol)s" (2014), represents a foundational contribution to the field of polymer-based imaging agents. In this study, she pioneered the direct comparison of poly(2-ethyl-2-oxazoline) (PEtOx) and poly(ethylene glycol) (PEG) as stealth coatings for nanoparticles, demonstrating that PEtOx offers comparable or superior in vivo performance while avoiding the immunogenicity issues associated with PEG. This work has been cited over 200 times, underscoring its impact on the design of next-generation nanomedicines. Beyond this landmark paper, Wyffels has advanced the preclinical validation of 89Zr-labeled antibodies and peptides for cancer imaging, contributing to the broader translation of immuno-PET. Her meticulous approach to radiochemistry and quantitative imaging has made her a respected figure in the European molecular imaging community, with her research directly informing clinical trial design for targeted radiotherapeutics.