Leon Douglas
Papers
1
Total Citations
16
H-Index
1
About
Leon Douglas is a chemical biologist whose work centers on the development of high-throughput screening methodologies for kinase inhibitor discovery. His most cited study, "High-Throughput Screening Assay for Identification of Small Molecule Inhibitors of Aurora2/STK15 Kinase" (2004, 16 citations), established a robust, cell-free assay platform to identify small-molecule modulators of the mitotic regulator Aurora2/STK15. This contribution provided an early, scalable tool for probing the kinase’s role in cell cycle control and oncogenesis, laying groundwork for subsequent therapeutic targeting. While his citation count reflects a focused, early-career impact, Douglas’s work exemplifies the critical translational step between basic kinase biology and preclinical drug discovery. His assay design remains a reference point for researchers seeking to adapt fluorescence-based screening to challenging kinase targets, underscoring his role in advancing the chemical biology toolkit for cancer research.
Research Focus
Key Achievements
Top Papers
- 1