Laura Di Renzo

Institute of Molecular Biology and Pathology

Papers

Total Citations

H-Index

About

Laura Di Renzo is a pioneering biochemist whose work has significantly advanced the study of viral proteases, particularly in the context of hepatitis C virus (HCV) research. Her key contributions center on the development of high-throughput screening methodologies for antiviral drug discovery. Di Renzo’s most cited paper, "A High-Throughput Radiometric Assay for Hepatitis C Virus NS3 Protease" (1999), introduced a novel, efficient assay that enabled rapid identification of inhibitors targeting the HCV NS3 protease—a critical enzyme for viral replication. This work laid the groundwork for subsequent breakthroughs in HCV therapeutics, directly influencing the development of direct-acting antiviral agents that have since transformed hepatitis C treatment. With 14 citations, this foundational study remains a reference point for researchers in virology and drug development. Di Renzo’s methodological innovations exemplify how precise assay design can accelerate the path from basic research to clinical applications, underscoring her role as a key figure in the fight against viral diseases. Her legacy continues to inspire students and researchers exploring protease-targeted therapies.