Katlin B. Massirer
Papers
1
Total Citations
2
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About
Katlin B. Massirer is a structural biologist and chemical geneticist whose research focuses on the molecular mechanisms of post-translational modifications and their roles in disease, particularly in malaria. Her major contributions center on the hypusine pathway, which modifies the translation factor eIF5A—the only protein known to contain this unique amino acid. Massirer led the development of an experimental target-based platform in yeast for screening inhibitors of *Plasmodium vivax* deoxyhypusine synthase (DHS), a critical enzyme in this pathway. This work, published in 2024, provides a powerful tool for discovering antimalarial compounds that target an essential and conserved modification process. Her research has implications for both infectious disease and cancer, as dysregulation of the hypusine pathway is linked to cell proliferation. Though early in its citation impact, her platform approach represents a notable achievement in bridging yeast genetics and drug discovery. Massirer’s work underscores the importance of understanding fundamental biochemical pathways to develop targeted therapies against parasitic infections.
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Top Papers
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