Cleslei Fernando Zanelli
Papers
1
Total Citations
2
H-Index
1
About
Cleslei Fernando Zanelli is a leading researcher in molecular biology and biochemistry, with a primary focus on the post-translational modification of eukaryotic translation factor 5A (eIF5A) and its regulatory enzyme, deoxyhypusine synthase (DHS). His work has significantly advanced the understanding of the hypusination pathway—a unique and essential modification found only in eIF5A—and its role in cellular proliferation and disease. Zanelli’s major contributions include pioneering an experimental target-based platform in yeast for screening inhibitors of *Plasmodium vivax* DHS, as detailed in his 2024 study (2 citations). This innovative approach provides a powerful tool for antimalarial drug discovery, targeting a pathway critical for parasite growth. His research has broad implications for infectious disease and cancer biology, where eIF5A dysregulation is implicated. With a growing citation impact, Zanelli’s work bridges fundamental biochemistry and translational applications, establishing him as a key figure in hypusine biology and a contributor to novel therapeutic strategies against malaria.
Research Focus
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Top Papers
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