Kathrin Motzny
Papers
2
Total Citations
81
H-Index
2
About
Kathrin Motzny is a molecular biologist whose research has significantly advanced our understanding of protein-protein interactions, specifically those mediated by GYF domains. Her work centers on the structural and functional characterization of these conserved eukaryotic adaptor domains, which recognize proline-rich sequences critical for intracellular signaling and splicing. Motzny’s most influential contribution is her 2005 study, “GYF Domain Proteomics Reveals Interaction Sites in Known and Novel Target Proteins,” which has garnered 54 citations. This work expanded the known interactome of GYF domains beyond the prototypic human CD2BP2 protein, identifying novel binding partners and interaction sites. In a complementary 2005 study (27 citations), she developed a general approach to uncover new interaction partners for the CD2BP2-GYF domain, moving beyond the previously known targets CD2 and SmB/B′. By systematically mapping these networks, Motzny has provided foundational insights into how GYF domains mediate diverse cellular processes, from T cell adhesion to pre-mRNA splicing. Her research remains a key reference for scientists studying adaptor proteins and post-transcriptional regulation.
Research Focus
Key Achievements
Top Papers
- 1
- 2Novel Interaction Partners of the CD2BP2-GYF Domain27 citations · 2005