Kathleen Jennings
Papers
1
Total Citations
6
H-Index
1
About
Kathleen Jennings is a pharmaceutical scientist whose work has centered on bioanalytical method development, particularly for neuroactive compounds. Her key research area involves high-performance liquid chromatography (HPLC) for quantifying drugs in biological matrices, a critical tool for pharmacokinetic and drug development studies. Her most cited contribution is a validated HPLC assay for CI-988, a non-peptide cholecystokinin-B (CCK-B) receptor antagonist investigated for anxiety and pain. This method, published in 1995, demonstrated high sensitivity and specificity for measuring the drug in human and monkey plasma, employing robotic sample preparation to enhance throughput and reliability. While her citation count for this work is modest at six, the study represents a foundational technical achievement in bioanalysis, enabling accurate preclinical and clinical monitoring of a then-novel therapeutic candidate. Jennings’ contribution highlights the essential, behind-the-scenes role of analytical chemistry in advancing neuroscience drug discovery, ensuring that promising compounds like CI-988 could be safely and effectively evaluated in living systems.
Research Focus
Key Achievements
Top Papers
- 1