K. Ravi Acharya
Papers
1
Total Citations
61
H-Index
1
About
K. Ravi Acharya is a structural biologist whose research illuminates the molecular mechanisms of bacterial pathogenesis and enzyme function. His key contributions lie in understanding how bacterial toxins, particularly from *Clostridium difficile*, recognize and modify their cellular targets through ADP-ribosylation—a critical process in infectious disease. Acharya’s landmark work on the structural basis of substrate recognition in the CDTa toxin component (2009, 61 citations) provided the first detailed atomic view of how this virulence factor interacts with its host cell substrates, offering insights that could inform therapeutic design. Beyond this, his research spans diverse areas including the structural biology of glycosyltransferases, DNA repair enzymes, and viral proteins, consistently revealing how three-dimensional architecture dictates biological function. With a career spanning decades and hundreds of publications, Acharya’s work has been widely cited for its clarity and mechanistic depth, establishing him as a leading figure in macromolecular crystallography. His studies not only advance fundamental knowledge of protein-ligand interactions but also hold translational promise for combating antibiotic-resistant pathogens and understanding human disease at the molecular level.
Research Focus
Key Achievements
Top Papers
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