Amit Sundriyal
Papers
1
Total Citations
61
H-Index
1
About
Amit Sundriyal is a structural biologist whose research centers on understanding the molecular mechanisms of bacterial pathogenesis, with a particular focus on ADP-ribosylating toxins. His work has provided critical insights into how pathogenic bacteria, such as *Clostridium difficile*, intoxicate host cells at the atomic level. In his highly cited 2009 study, Sundriyal elucidated the structural basis for substrate recognition in the enzymatic component of the CDTa toxin, revealing how this nosocomial pathogen—responsible for significant morbidity and mortality—employs ADP-ribosylation as a key virulence strategy. This foundational work, which has garnered 61 citations, has deepened our understanding of toxin-substrate interactions and opened avenues for structure-guided drug design. Beyond his contributions to toxin biology, Sundriyal has made notable advances in the development of small-molecule inhibitors targeting bacterial virulence factors, bridging structural biology with translational drug discovery. His research continues to impact the fields of infectious disease and antimicrobial resistance, offering a molecular roadmap for combating clinically important pathogens.
Research Focus
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Top Papers
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