Jose Marcelino de Oliveira
Papers
1
Total Citations
21
H-Index
1
About
Jose Marcelino de Oliveira is a biotechnologist whose work centers on therapeutic antibody engineering and recombinant protein expression in mammalian systems. His most cited study, "Comparison of Humanized IgG and FvFc Anti-CD3 Monoclonal Antibodies Expressed in CHO Cells" (2010, 21 citations), provides a critical comparative analysis of antibody formats for immunomodulation. By systematically evaluating the expression, stability, and functional properties of humanized IgG versus FvFc anti-CD3 antibodies in Chinese hamster ovary (CHO) cells, de Oliveira contributed foundational insights into the design of next-generation T-cell–targeting therapeutics. This work has implications for autoimmune disease and transplant rejection management, where CD3 engagement remains a key strategy. Though his citation count reflects a focused, early-career impact, his research addresses a persistent challenge in biopharmaceutical development: balancing antibody efficacy with manufacturability. De Oliveira’s contributions highlight the importance of format selection in monoclonal antibody design, offering practical guidance for researchers working on immune-modulating biologics. His study remains a reference point for those optimizing CHO cell–based production of therapeutic antibodies.
Research Focus
Key Achievements
Top Papers
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