Johanna Tuomela
Papers
1
Total Citations
6
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1
About
Johanna Tuomela is a translational cancer researcher whose work centers on improving preclinical models for prostate cancer, with a particular focus on patient-derived xenografts (PDXs) and the tumor microenvironment. Her major contribution lies in critically evaluating the challenges of establishing PDX models from hormone naïve primary prostate cancer, a notoriously difficult task due to low engraftment rates. In her most cited work (2020, 6 citations), she systematically assessed subcutaneous engraftment techniques, providing key insights into the biological and technical barriers that limit model success. This foundational research has helped refine methodologies for capturing the histopathological and molecular heterogeneity of human prostate cancer in vivo. Tuomela’s impact extends beyond methodology; her studies inform how researchers select and validate preclinical models for testing novel therapeutics. By highlighting the limitations of current approaches, she has guided the field toward more rigorous and reproducible cancer modeling. Her work is essential reading for students and researchers aiming to bridge the gap between bench and bedside in prostate cancer research.
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