Jeremy S. Caldwell
Papers
1
Total Citations
185
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1
About
Jeremy S. Caldwell is a pioneering chemical biologist and drug discovery researcher whose work has fundamentally advanced how we profile and understand the activities of molecular libraries. His most recognized contribution is the development of an efficient, rapid system for characterizing small molecules, peptides, proteins, and RNAs across a broad array of cellular assays—a methodology detailed in his highly cited 2006 paper (185 citations). This breakthrough enables researchers to discover new biological activities and generate comprehensive activity profiles for drug candidates early in the development pipeline, dramatically accelerating the path from molecule to medicine. Caldwell’s approach has been instrumental in moving beyond traditional single-target screening toward systems-level cellular profiling, allowing for the identification of both on-target effects and off-target toxicities. His work has had a lasting impact on the fields of chemical biology and early-stage drug development, providing a foundational tool for researchers seeking to understand the full biological consequences of chemical matter. Caldwell’s contributions continue to influence how academic and pharmaceutical labs approach the characterization of molecular libraries.
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Top Papers
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