Jeffrey A. Pleiss
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1
Total Citations
32
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1
About
Jeffrey A. Pleiss is a molecular biologist whose work has fundamentally advanced our understanding of pre-mRNA splicing and its integration with other steps of gene expression. His research focuses on the intricate regulatory networks that govern RNA processing in eukaryotic cells, particularly in the model organism *Saccharomyces cerevisiae*. Pleiss is best known for developing and implementing a groundbreaking, high-throughput reverse genetic screen that couples robotic RNA isolation with quantitative PCR. This innovative approach, detailed in his highly cited 2012 study (32 citations), enabled a genome-wide, quantitative analysis of splicing defects, revealing novel and unexpected connections between pre-mRNA splicing and the determinants of 5′ and 3′ transcript ends. By systematically dissecting these relationships, his work has provided critical insights into how cells coordinate the complex machinery of RNA production and processing. Pleiss’s contributions have not only illuminated fundamental biological principles but have also established powerful new methodologies for the field, making him a key figure in the study of post-transcriptional gene regulation.
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