Janna Holmgren
Papers
1
Total Citations
26
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1
About
Janna Holmgren is a biochemist whose research focuses on the enzymatic mechanisms underlying cancer metastasis and inflammation, particularly through the study of heparanase. Her major contribution lies in pioneering high-throughput methodologies to measure heparanase activity, a critical enzyme that degrades the extracellular matrix and facilitates tumor cell invasion. Her most-cited work, "High-throughput methods for measuring heparanase activity and screening potential antimetastatic and anti-inflammatory agents" (2004, 26 citations), established a robust platform for rapidly identifying inhibitors of this enzyme. This breakthrough not only accelerated the discovery of novel therapeutic candidates but also provided a foundational tool for researchers investigating heparanase's role in disease progression. By enabling efficient screening of antimetastatic and anti-inflammatory agents, Holmgren’s work has directly impacted drug development pipelines, offering hope for more targeted treatments. Her methodological innovations continue to be referenced in studies exploring extracellular matrix remodeling, underscoring her lasting influence on the fields of cancer biology and inflammation research.
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Top Papers
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