James P. Malone
Papers
1
Total Citations
118
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About
James P. Malone is a leading figure in neuroproteomics, whose work has fundamentally shaped how researchers approach biomarker discovery for central nervous system disorders. His research centers on the molecular characterization of cerebrospinal fluid (CSF) and the critical challenge of distinguishing true disease signals from biological noise. Malone’s most influential contribution is his landmark 2005 study, “Comparative Proteomic Analysis of Intra- and Interindividual Variation in Human Cerebrospinal Fluid,” which has garnered 118 citations. This seminal work systematically quantified the natural variability of the CSF proteome both within a single person over time and across different individuals—a foundational step often overlooked in biomarker studies. By establishing a rigorous baseline for normal variation, Malone provided the field with essential guidelines for designing robust experiments, particularly for Alzheimer’s disease research. His meticulous approach has made him a trusted authority on experimental design in clinical proteomics, ensuring that subsequent biomarker candidates are evaluated against a realistic standard of biological variance.
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