James P Buteau
Papers
1
Total Citations
84
H-Index
1
About
James P Buteau is a leading clinical researcher in theranostics for prostate cancer, whose work bridges nuclear medicine and surgical oncology. His most impactful contribution is the LuTectomy trial, a landmark phase 1/2 study investigating the administration of [177Lu]Lu-PSMA-617 prior to radical prostatectomy in men with high-risk localised disease. This single-centre study, published in 2023 and already garnering 84 citations, demonstrated the feasibility and safety of delivering targeted radioligand therapy before surgery, opening a new frontier in neoadjuvant treatment paradigms. Buteau’s research focuses on optimising PSMA-targeted therapies—combining diagnostic imaging with therapeutic radiopharmaceuticals—to improve outcomes for patients with aggressive prostate cancer. His work has been instrumental in translating preclinical insights into clinical protocols, showing how PSMA-617 can reduce tumour burden prior to resection. By integrating molecular imaging and surgery, Buteau is helping to redefine the standard of care for high-risk localised disease, offering a personalised approach that may improve both surgical outcomes and long-term survival. His contributions are shaping the next generation of prostate cancer management.
Research Focus
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Top Papers
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