Jacek Klepacki
Papers
1
Total Citations
49
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1
About
Jacek Klepacki is a leading expert in bioanalytical chemistry and therapeutic drug monitoring, with a particular focus on immunosuppressant pharmacokinetics. His most impactful work centers on the development of high-throughput, robust mass spectrometry assays for quantifying drugs and their metabolites in complex biological matrices. Klepacki’s major contribution is a landmark 2011 study introducing a U-HPLC–MS/MS method for the simultaneous quantification of mycophenolic acid and its two key glucuronide metabolites in both human plasma and urine. This assay, which has garnered 49 citations, addressed a critical need for precise, efficient monitoring of this essential immunosuppressant in transplant patients, enabling more personalized dosing and improved clinical outcomes. His work exemplifies the translation of advanced analytical chemistry into practical clinical tools, bridging the gap between laboratory innovation and patient care. Klepacki’s research continues to shape the standards for bioanalytical method validation and application in pharmacokinetic studies.
Research Focus
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Top Papers
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