Jaap Wieling
Papers
2
Total Citations
81
H-Index
2
About
Jaap Wieling is a pioneering researcher in the field of bioanalytical chemistry, with a particular focus on high-throughput sample preparation and liquid chromatography-mass spectrometry (LC-MS) techniques applied to pharmaceutical analysis. Working primarily in the late 1990s, Wieling made significant contributions to the development of efficient, automated methods for determining drug concentrations in human plasma — a critical capability in pharmacokinetic studies and drug development pipelines. His most influential work centers on solid-phase extraction (SPE) technology coupled with advanced ionization and detection methods. His 1999 study on haloperidol determination using turbo ionspray LC-MS/MS (44 citations) demonstrated how high-throughput approaches could dramatically accelerate bioanalytical workflows without sacrificing sensitivity or precision. Complementing this, his 1998 work on cimetidine quantification (37 citations) further established robust SPE protocols adaptable across multiple pharmaceutical compounds. Wieling's research arrived at a transformative moment in drug analysis, helping to lay the groundwork for modern high-throughput bioanalytical laboratories. His methodologies have proven enduringly relevant, influencing how researchers and clinicians approach plasma drug monitoring and pharmacokinetic profiling in both research and clinical settings.
Research Focus
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