Jaakko O Nieminen

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About

Jaakko O. Nieminen is a leading researcher in non-invasive brain stimulation, with a particular focus on transcranial magnetic stimulation (TMS) and its precise application to human motor and cognitive systems. His most notable contribution is the development of a novel method for targeting multi-locus TMS using Bayesian optimization, a breakthrough that dramatically improves the spatial precision of dual-site stimulation by directing pulses toward functionally relevant neural pathways. This work, published in 2025, ensures tightly controlled interstimulus intervals, enabling more accurate investigations of cortico-cortical interactions. In a pilot experiment, his approach successfully elicited reliable motor evoked potentials, demonstrating its practical utility. Though early in its citation trajectory, this work represents a significant methodological advance in the field. Nieminen’s research sits at the intersection of computational modeling, optimization algorithms, and neurophysiology, offering powerful new tools for studying brain connectivity and plasticity. His contributions are particularly valuable for researchers designing closed-loop or adaptive stimulation protocols, and his work promises to shape the next generation of targeted brain stimulation therapies.