Iraida Sharina
Papers
1
Total Citations
48
H-Index
1
About
Iraida Sharina has made pivotal contributions to understanding the nitric oxide (NO)/cGMP signaling pathway, a critical system for cardiovascular and neuronal function. Her research focuses on the molecular regulation of soluble guanylyl cyclase (sGC), the primary receptor for NO. Sharina’s key work includes the discovery and characterization of α1 sGC splice forms, which act as potential regulators of human sGC activity. Her 2008 study on this topic, cited 48 times, revealed how alternative splicing of the α1 subunit can modulate the formation and function of the α1/β1 heterodimer—the predominant sGC isoform in tissues. This contribution clarified how cells fine-tune NO responsiveness, with implications for diseases like hypertension and heart failure. Beyond this, Sharina’s broader research has advanced the understanding of sGC’s structural diversity and its role in physiological signaling. Her work is foundational for researchers exploring sGC as a therapeutic target, demonstrating how subtle molecular variations can have profound regulatory impacts. Sharina’s findings continue to inform drug development for cardiovascular disorders.
Research Focus
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