Elena Bogatenkova
Papers
1
Total Citations
48
H-Index
1
About
Elena Bogatenkova is a molecular biologist whose research has significantly advanced our understanding of the nitric oxide (NO)/cGMP signaling pathway, a critical system for cardiovascular and neurological function. Her work centers on the structural and functional regulation of soluble guanylyl cyclase (sGC), the primary receptor for NO. Bogatenkova’s most cited study (2008, 48 citations) identified and characterized novel α1 sGC splice forms, revealing that alternative splicing can generate variants with altered activity. This discovery challenged the prevailing view of sGC as a static heterodimer, suggesting instead that cells may fine-tune NO responsiveness through splice variant expression. By demonstrating that these splice forms could act as potential regulators of human sGC activity, her work opened new avenues for understanding tissue-specific NO signaling and for developing targeted therapies for diseases involving sGC dysfunction, such as hypertension and heart failure. Bogatenkova’s contributions remain foundational for researchers exploring the molecular diversity of NO signaling and its therapeutic implications.
Research Focus
Key Achievements
Top Papers
- 1