Papers
1
Total Citations
5
H-Index
1
About
Isabel Garcia-Saez is a structural biologist whose work has advanced our understanding of the molecular machinery of cell division. Her research focuses on the structure and function of kinetochore-associated proteins, particularly the motor protein CENP-E, a kinesin essential for proper chromosome attachment and positioning during mitosis. In her notable 2004 study, Garcia-Saez successfully crystallized the motor domain of human CENP-E, a critical step toward determining its three-dimensional structure. This work, which employed an automated crystallization procedure, provided the foundation for subsequent high-resolution studies of this key mitotic regulator. While her most-cited paper has garnered 5 citations, its significance lies in enabling deeper structural insights into how CENP-E functions as a microtubule-dependent motor. By elucidating the architecture of this protein, Garcia-Saez has contributed to a broader understanding of the mechanical processes that ensure accurate chromosome segregation, with implications for cancer biology where these pathways are often disrupted.
Research Focus
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Top Papers
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