Delphine Blot
Papers
1
Total Citations
5
H-Index
1
About
Delphine Blot’s research career has centered on the molecular mechanics of cell division, with a particular focus on the kinetochore—the protein complex that orchestrates chromosome movement during mitosis. Her most cited work, a 2004 study on the crystallization of the motor domain of CENP-E, a kinesin-like protein essential for correct chromosome attachment and positioning, laid critical groundwork for understanding how this motor ensures faithful segregation. Though her citation counts are modest, with this key paper accruing 5 citations, its significance lies in its technical contribution: employing an automated crystallization procedure to obtain preliminary structural data on a human protein that is transiently localized to the kinetochore. This work provided a foundation for subsequent studies into the molecular basis of kinetochore-microtubule interactions and the errors that can lead to aneuploidy and cancer. Blot’s research exemplifies the painstaking structural biology required to illuminate the fundamental processes of life, and her focus on CENP-E places her among the scientists who have helped decode the intricate choreography of cell division.
Research Focus
Key Achievements
Top Papers
- 1