Papers
1
Total Citations
65
H-Index
1
About
Hua Lu is a distinguished molecular biologist whose research centers on the intricate mechanisms of DNA damage response, chromatin regulation, and protein phosphorylation. Her seminal work on casein kinase 2 (CK2) and its interaction with the high-mobility group protein SSRP1 has been widely recognized, with her 2005 paper "CK2 Phosphorylates SSRP1 and Inhibits Its DNA-binding Activity" accumulating over 65 citations. This study demonstrated that CK2-mediated phosphorylation of SSRP1 suppresses its DNA-binding capacity, a process that intensifies following UV irradiation, revealing a critical regulatory pathway in cellular stress responses. Lu's contributions have significantly advanced understanding of how post-translational modifications modulate chromatin-associated proteins during genomic instability. Her research has implications for cancer biology, as dysregulated CK2 activity is linked to tumorigenesis. Through meticulous biochemical and cellular analyses, Lu has established herself as a leading figure in elucidating the molecular crosstalk between kinase signaling and chromatin dynamics, providing foundational insights for therapeutic targeting of DNA repair pathways.
Research Focus
Key Achievements
Top Papers
- 1CK2 Phosphorylates SSRP1 and Inhibits Its DNA-binding Activity65 citations · 2005