David M. Keller
Papers
1
Total Citations
65
H-Index
1
About
David M. Keller is a molecular biologist whose research centers on the cellular response to DNA damage and the regulatory roles of protein kinases. His most cited work, a 2005 study on CK2-mediated phosphorylation of SSRP1, revealed a novel mechanism by which CK2 inhibits SSRP1’s DNA-binding activity, a process amplified after UV irradiation. This discovery, garnering 65 citations, illuminates how post-translational modifications fine-tune chromatin-associated proteins during genotoxic stress. Keller’s contributions have advanced understanding of kinase signaling in genome stability, particularly the interplay between CK2 and high-mobility group proteins. His work is foundational for researchers exploring DNA repair pathways and cancer biology, where CK2 dysregulation is common. By linking phosphorylation events to functional outcomes, Keller provides critical insights into how cells safeguard genomic integrity. His findings continue to inspire investigations into targeted therapies for diseases driven by aberrant kinase activity.
Research Focus
Key Achievements
Top Papers
- 1CK2 Phosphorylates SSRP1 and Inhibits Its DNA-binding Activity65 citations · 2005