Guadalupe Sabio

MRC Protein Phosphorylation and Ubiquitylation Unit

Papers

Total Citations

310

H-Index

About

Guadalupe Sabio is a leading figure in stress signaling and metabolism, whose research has fundamentally advanced our understanding of how p38 MAP kinases and other stress-responsive pathways regulate metabolic and inflammatory diseases. Her work has uncovered critical roles for these kinases in obesity, insulin resistance, and non-alcoholic fatty liver disease, bridging basic cell signaling with whole-organism physiology. Among her most influential contributions is the landmark 2005 study demonstrating that the clinical compound BIRB796 inhibits all p38 MAPK isoforms, including p38γ, at higher concentrations—a finding with direct implications for anti-inflammatory drug development. This paper alone has garnered over 310 citations, reflecting its lasting impact on both basic and translational research. Sabio’s group has also made pioneering discoveries on the interplay between stress kinases and mitochondrial function, and her work is widely recognized for its mechanistic depth and therapeutic potential. A prolific researcher, she has published extensively in top-tier journals and has been honored with multiple prestigious awards, including an ERC Consolidator Grant. Her research continues to shape our understanding of how cellular stress responses drive metabolic dysfunction and disease.