Frauke Grabbe
Papers
1
Total Citations
13
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1
About
Frauke Grabbe has made foundational contributions to neurogenomics, with a focus on mapping the expression landscapes of ion channels in the developing mammalian brain. Her most-cited work, "A Digital Atlas of Ion Channel Expression Patterns in the Two-Week-Old Rat Brain" (2014, 13 citations), stands as a landmark resource in the field. In this study, Grabbe and her team systematically determined the expression patterns of 320 ion channels—nearly the entire complement encoded by the mammalian genome—in the P14 rat brain. To achieve this, she pioneered non-radioactive robotic in situ hybridization methods, enabling high-throughput, spatially precise profiling of channel distribution across brain regions. This digital atlas provides an essential reference for understanding how ion channels underpin neural excitability, synaptic transmission, and network development during a critical postnatal window. By bridging molecular neurobiology with systems-level anatomy, Grabbe’s work has empowered researchers to link channelopathies to specific circuits and developmental disorders. Her methodological innovations and comprehensive dataset continue to inform studies in neurodevelopment, epilepsy, and channel-targeted therapeutics, cementing her impact on the neuroscience community.
Research Focus
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Top Papers
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