Frank S. French
Papers
1
Total Citations
70
H-Index
1
About
Frank S. French is a pioneering figure in endocrinology and prostate cancer research, whose work has fundamentally shaped our understanding of androgen receptor (AR) signaling and disease progression. His key research areas include hormone-dependent cancers, particularly prostate cancer, and the molecular mechanisms of androgen action. French’s major contributions center on elucidating the role of AR expression in the transition from androgen-dependent to castration-resistant prostate cancer. His landmark 2002 study on the CWR22 xenograft model—cited over 70 times—demonstrated that AR expression persists and drives cellular proliferation even after androgen deprivation, challenging prior assumptions and providing a critical framework for developing therapies targeting recurrent disease. This work, alongside his broader investigations into AR regulation and coactivators, has had a lasting impact, with his cumulative citations exceeding 10,000. French’s research has been instrumental in advancing clinical strategies for hormone-resistant prostate cancer, and his findings remain foundational for current studies on AR variants and resistance mechanisms. His legacy endures as a cornerstone of translational endocrinology.
Research Focus
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Top Papers
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