Florent Clerc
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1
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92
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About
Florent Clerc is a leading figure in the field of glycomics, with a primary focus on the high-throughput analysis of protein glycosylation. His most significant contribution is the development of a robust, automated MALDI-TOF mass spectrometry method for comprehensive human plasma N-glycan profiling. Clerc’s landmark 2015 paper, which has garnered 92 citations, introduced a critical innovation: linkage-specific sialic acid esterification. This technique allows for the precise differentiation of sialic acid linkages, a key structural feature that is often altered in disease states. By automating this complex derivatization process, Clerc has enabled the high-throughput, reproducible analysis of N-glycomes, transforming a traditionally labor-intensive procedure into a scalable tool for clinical research. His work has laid the essential methodological groundwork for using plasma glycomics as a diagnostic and prognostic tool in diseases like cancer and inflammation, making him a pivotal figure in translating complex glycobiology into practical biomedical applications.
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