Fanny A. Pelissier Vatter
Papers
1
Total Citations
25
H-Index
1
About
Fanny A. Pelissier Vatter is a cancer biologist whose work illuminates how the tumor microenvironment drives drug resistance and epithelial plasticity. Her research centers on the non-genetic mechanisms that allow cancer cells to evade therapy, with a particular focus on receptor tyrosine kinases like AXL and cKIT. In her highly cited 2018 study (25 citations), she demonstrated that specific microenvironments can impose non-sporadic expression of these receptors, challenging the prevailing view that drug-tolerant cells arise purely through stochastic epigenetic events. This work provides a mechanistic framework for understanding how spatial cues within tumors can systematically induce a plastic, drug-resistant state. Pelissier Vatter’s contributions are significant for their potential to identify microenvironmental vulnerabilities that could be targeted to prevent or reverse acquired resistance. Her findings have implications for combination therapy strategies, particularly in cancers where AXL and cKIT signaling are implicated in metastatic progression and treatment failure.
Research Focus
Key Achievements
Top Papers
- 1