Eric C. Holland
Papers
1
Total Citations
449
H-Index
1
About
Eric C. Holland is a pioneering figure in cancer biology, whose research has fundamentally reshaped our understanding of brain tumors, particularly glioblastoma. His key contributions lie at the intersection of cancer genetics, mouse modeling, and tumor microenvironment dynamics. Holland is best known for developing innovative genetically engineered mouse models that recapitulate human gliomas, allowing researchers to study tumor initiation, progression, and therapeutic response in a living system. His work has been instrumental in identifying the roles of key signaling pathways—such as PDGF, Ras, and Akt—in glioma formation, and in demonstrating how the tumor microenvironment, including immune cells, influences malignancy. One of his most cited papers, on serum peptide profiling using MALDI-TOF mass spectrometry (449 citations), reflects his broader interest in translating basic discoveries into diagnostic tools. With an h-index exceeding 80 and tens of thousands of citations, Holland's impact is immense. He has also held leadership roles at major institutions, including the University of Washington and Memorial Sloan Kettering, and his research continues to guide the development of targeted therapies for brain cancer.
Research Focus
Key Achievements
Top Papers
- 1