Ekaterina Posokhova
Papers
1
Total Citations
34
H-Index
1
About
Ekaterina Posokhova is a molecular biologist whose research centers on the molecular mechanisms of retinal degeneration, with a particular focus on protein folding and its role in photoreceptor cell survival. Her most cited work, "Disruption of the Chaperonin Containing TCP-1 Function Affects Protein Networks Essential for Rod Outer Segment Morphogenesis and Survival" (2010, 34 citations), represents a significant contribution to understanding how the CCT/TRiC chaperonin complex—a multi-subunit molecular machine responsible for folding approximately 10% of newly translated cytosolic proteins—is essential for maintaining the structural integrity and function of rod photoreceptors. This study demonstrated that CCT dysfunction disrupts protein networks critical for rod outer segment morphogenesis, leading to photoreceptor degeneration. Posokhova's work bridges fundamental cell biology with vision science, providing insights into how protein folding deficits can contribute to retinal disease. Her research has implications for understanding the pathogenesis of inherited retinal degenerations and highlights potential therapeutic targets for preserving vision.
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Top Papers
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