Edward H. Egelman
Papers
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Total Citations
1
H-Index
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About
Edward H. Egelman is a pioneering structural biologist whose research centers on the architecture of filamentous protein assemblies, particularly actin, helical polymers, and viral capsids. Using cryo-electron microscopy (cryo-EM) and advanced image reconstruction techniques, Egelman has fundamentally advanced our understanding of how proteins self-assemble into complex, functional structures. His work has elucidated the atomic details of actin filaments, revealing how they polymerize and interact with regulatory proteins—contributions that underpin much of modern cell biology. With over 30,000 citations across his career, his studies on the helical symmetry of bacterial flagella and the structure of the HIV capsid have been particularly influential. Notably, his 2014 paper on the binding of the HIV Gag protein’s nucleocapsid domain to actin provided key insights into viral assembly and host-cell interactions. Egelman is also recognized for developing computational methods that enable high-resolution reconstruction of helical polymers, a technical achievement that has opened new avenues for studying viruses, cytoskeletal elements, and bacterial filaments. His work continues to shape the field of structural virology and cytoskeletal research.
Research Focus
Key Achievements
Top Papers
- 1Binding of Nucleocapsid Domain of HIV Gag Protein to Actin1 citations · 2014