Dennis J. Selkoe
Papers
1
Total Citations
113
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About
Dennis J. Selkoe is a pioneering neuroscientist whose groundbreaking research has fundamentally shaped our understanding of Alzheimer’s disease. His key contributions center on the molecular mechanisms of amyloid β-protein (Aβ) accumulation and clearance in the brain. Selkoe’s work has been instrumental in establishing that proteases regulating Aβ degradation are critical determinants of brain Aβ levels, influencing both healthy aging and Alzheimer’s pathology. Among his notable achievements, he developed innovative fluorescence- and fluorescence polarization-based assays to quantify Aβ degradation kinetics, providing robust tools that have been widely adopted (his 2003 paper on this topic has garnered 113 citations). These methods enabled precise measurement of protease activity, advancing the search for therapeutic strategies to enhance Aβ clearance. With tens of thousands of citations across his career, Selkoe’s research has not only elucidated disease mechanisms but also paved the way for clinical trials targeting Aβ metabolism. A member of the National Academy of Sciences, his work remains foundational for students and researchers exploring Alzheimer’s pathogenesis and therapeutic interventions.
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