David B. Teplow
Papers
2
Total Citations
119
H-Index
2
About
David B. Teplow is a leading neuroscientist whose research has fundamentally advanced our understanding of the molecular mechanisms underlying Alzheimer’s disease and other neurodegenerative disorders of aging. His primary focus lies in the biophysics and biochemistry of the amyloid β-protein (Aβ), particularly the kinetics of its aggregation and degradation—processes central to Alzheimer’s pathology. Teplow’s major contributions include the development of novel fluorescence- and fluorescence polarization-based assays that enable precise, quantitative measurement of Aβ degradation kinetics. This work, published in a highly cited 2003 paper (113 citations), provided researchers with robust tools to study proteases that regulate brain Aβ levels, offering critical insights into both healthy aging and disease progression. Additionally, Teplow has been instrumental in fostering interdisciplinary collaboration, as evidenced by his 2006 paper highlighting common threads among neurodegenerative diseases like Alzheimer’s and Huntington’s. By bridging molecular biology and clinical neurology, his research has paved the way for targeted therapeutic strategies. A respected figure in the field, Teplow’s work continues to inspire students and researchers seeking to unravel the complexities of protein misfolding and neurodegeneration.
Research Focus
Key Achievements
Top Papers
- 1
- 2Common threads in neurodegenerative disorders of aging6 citations · 2006