D. E. Nelson
Papers
1
Total Citations
10
H-Index
1
About
Dr. D. E. Nelson is a clinical biochemist whose work has advanced the accurate measurement of vitamin B12 status through mass spectrometry. Her primary research focuses on developing and validating robust analytical methods for quantifying biomarkers of nutritional deficiency, with a particular emphasis on methylmalonic acid (MMA)—a sensitive indicator of functional B12 deficiency. Her most cited work, a 2012 paper on the semi-automated quantification of MMA in human serum using LC-MS/MS, introduced a streamlined approach that replaced labor-intensive manual extraction and derivatization steps common in GC-MS methods. This innovation improved throughput and reproducibility in clinical laboratories, directly impacting the diagnosis of B12 deficiency in patients with neurological or hematological disorders. With 10 citations, this methodological contribution has been referenced by researchers seeking efficient, high-sensitivity protocols for MMA analysis. Dr. Nelson’s work bridges the gap between analytical chemistry and clinical diagnostics, ensuring that reliable biomarker measurements support timely medical interventions. Her dedication to method optimization continues to influence laboratory practice in nutritional biochemistry.
Research Focus
Key Achievements
Top Papers
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