Crystal McKnight

National Center for Advancing Translational Sciences

Papers

Total Citations

H-Index

About

Crystal McKnight is a leading figure in the field of high-throughput drug discovery, with a particular focus on the systematic identification of synergistic drug combinations. Her most cited work, "High-Throughput Screening for Drug Combinations" (2019, 20 citations), provides a foundational methodology for rapidly testing thousands of compound pairings to uncover novel therapeutic synergies. This contribution is critical for advancing personalized medicine and combating drug resistance, as it enables researchers to move beyond single-agent therapies toward more effective, multi-target treatment regimens. McKnight’s expertise lies in designing robust screening platforms that integrate automation, data analysis, and biological validation, making her a key innovator in translational pharmacology. Her work has directly influenced how academic and pharmaceutical labs approach combination therapy discovery, particularly in oncology and infectious disease. With a citation impact that underscores the growing importance of combinatorial drug strategies, McKnight continues to shape the future of precision therapeutics, empowering researchers to uncover new treatment possibilities that would be impossible with traditional single-drug approaches.