Chin Ha Chung

Papers

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About

Chin Ha Chung has made foundational contributions to the understanding of ubiquitin-like protein modifications, particularly through his work on the Ufm1 system. His research focuses on the structural and functional characterization of proteases that process ubiquitin-fold modifiers, with his most cited study (2008, 59 citations) revealing the molecular basis for Ufm1 processing by UfSP1. This work demonstrated that Ufm1, like ubiquitin, requires C-terminal glycine exposure before conjugation, and identified two novel proteases critical to this pathway. Chung's findings have been instrumental in elucidating how Ufm1 conjugation regulates cellular stress responses and protein homeostasis. His research has garnered significant attention, with his papers collectively cited over 1,200 times, reflecting the impact of his discoveries on the fields of protein degradation and post-translational modification. By uncovering the structural mechanisms of Ufm1 processing, Chung has opened new avenues for understanding the roles of ubiquitin-like modifiers in human diseases, including cancer and neurodegeneration. His work continues to inspire researchers exploring the diverse functions of the ubiquitin-proteasome system.