Chengjun Li
Papers
1
Total Citations
65
H-Index
1
About
Chengjun Li has made significant contributions to the understanding of protein-protein interactions, particularly through the study of Src homology 3 (SH3) domains. His key research areas include proteomics, molecular recognition, and signal transduction. Li’s most notable work, a 2005 study with 65 citations, identified novel SH3 domain-binding motifs from a proteomic screen of proline-rich regions. This research revealed that SH3 domains can bind peptide sequences lacking the canonical PXXP motif, expanding the known repertoire of ligand recognition. By investigating the diverse specificity of 15 SH3 domains using peptide arrays derived from the proline-rich region of the SH2 domain, Li provided critical insights into the complexity of cellular signaling networks. His findings have implications for understanding disease mechanisms and designing targeted therapeutics. Li’s work remains a valuable resource for researchers exploring molecular interactions and the dynamic regulation of signaling pathways.
Research Focus
Key Achievements
Top Papers
- 1