Chaim A. Schramm
Papers
1
Total Citations
37
H-Index
1
About
Chaim A. Schramm is a leading computational immunologist whose work bridges bioinformatics and antibody discovery to combat HIV-1. His research focuses on understanding B-cell immunity through the lens of antibodyomics—the large-scale analysis of antibody repertoires using next-generation sequencing and computational modeling. Schramm’s major contributions include developing bioinformatics technologies that trace the co-evolution of antibodies and viruses, revealing how broadly neutralizing antibodies (bnAbs) emerge during HIV-1 infection. His landmark 2017 paper, “Antibodyomics: bioinformatics technologies for understanding B‑cell immunity to HIV‑1,” has garnered 37 citations and remains a foundational resource for vaccine design. By mapping the genetic and structural pathways of bnAb development, Schramm’s work provides critical insights for eliciting similar antibodies through vaccination—a key step toward an effective HIV-1 vaccine. His achievements have positioned him at the forefront of computational immunology, where his tools and analyses continue to shape strategies for B cell-mediated vaccine development.
Research Focus
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Top Papers
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