Burckhard Seelig
Papers
1
Total Citations
264
H-Index
1
About
Burckhard Seelig is a pioneering biochemist and protein engineer whose work bridges synthetic biology and molecular recognition. His research focuses on developing novel peptide tags and affinity tools for protein purification, as well as engineering enzymes with enhanced or entirely new functions. Seelig’s most cited contribution is the development of the SBP-tag, a nanomolar-affinity streptavidin-binding peptide that enables one-step purification of recombinant proteins. This simple yet powerful method, described in a 2001 paper with 264 citations, has become a widely adopted tool in molecular biology and biotechnology laboratories worldwide. Beyond this landmark achievement, Seelig has made significant advances in directed evolution and computational protein design, creating artificial enzymes and biosensors with applications in diagnostics and biocatalysis. His work exemplifies how fundamental insights into protein-ligand interactions can be translated into practical technologies. For students and researchers, Seelig’s career demonstrates the impact of clever molecular engineering—turning a short peptide sequence into a transformative purification tool that continues to enable countless experiments across the life sciences.
Research Focus
Key Achievements
Top Papers
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