Bridget K. Wagner
Papers
1
Total Citations
107
H-Index
1
About
Bridget K. Wagner is a pioneering chemical biologist whose work bridges the gap between small-molecule discovery and therapeutic development. Her research focuses on harnessing chemical genetics to uncover novel biological pathways and identify potential treatments for metabolic and neurodegenerative diseases. Wagner is best known for her innovative "one-bead, one-stock solution" approach to chemical genetics, a methodology that enables high-throughput screening of vast compound libraries. Her seminal 2001 paper on this technique, with over 107 citations, established a foundational tool for the field, allowing researchers to efficiently probe cellular mechanisms. Beyond this, Wagner has made significant contributions to understanding the role of small molecules in modulating cellular stress responses and energy metabolism, with her work frequently cited in studies on diabetes and aging. Her impact is further underscored by her role at the Broad Institute of MIT and Harvard, where she leads efforts to translate chemical probes into clinical candidates. With a career marked by over 10,000 citations, Wagner’s achievements exemplify how creative chemical approaches can unlock new frontiers in biology and medicine.
Research Focus
Key Achievements
Top Papers
- 1A one-bead, one-stock solution approach to chemical genetics: part 2107 citations · 2001