Arpi Nazarian
Papers
2
Total Citations
115
H-Index
2
About
Arpi Nazarian is a pioneering researcher in functional proteomics, specializing in the development of innovative tools to profile enzyme activities within complex biological systems. Her work centers on creating “functional” biomarkers—detecting genuine enzymatic activity rather than static protein abundance—to reveal real-time biochemical processes in health and disease. Nazarian’s major contributions include the invention of the Sequence-specific Exopeptidase Activity Test (SSEAT), a groundbreaking method for discovering activity-based biomarkers, detailed in her most-cited paper (86 citations). She further advanced the field by demonstrating how MALDI-TOF mass spectrometry can monitor peptidase activities in complex proteomes (29 citations), enabling high-sensitivity, real-time tracking of proteolytic events. These techniques have profound implications for diagnostics and therapeutic monitoring, as they capture dynamic enzyme functions often missed by conventional proteomics. Nazarian’s work bridges mass spectrometry and enzymology, offering a powerful lens to study disease mechanisms. Her innovative approach has positioned her as a key figure in functional biomarker discovery, inspiring new avenues for precision medicine and molecular diagnostics.
Research Focus
Key Achievements
Top Papers
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