Anne Jorunn Stokka
Papers
1
Total Citations
66
H-Index
1
About
Anne Jorunn Stokka is a leading cell biologist whose research has fundamentally advanced our understanding of how cells orchestrate signaling through compartmentalization. Her primary focus is on the molecular architecture of A-kinase anchoring proteins (AKAPs) and their critical role in targeting Protein Kinase A (PKA) to specific subcellular locations. Her landmark 2008 study, cited over 66 times, revealed a groundbreaking discovery: dual-specificity AKAPs possess an additional binding region that allows them to anchor PKA type I, not just the previously known type II. This work challenged the established dogma of PKA anchoring and provided a new framework for understanding how cells achieve precise signaling specificity. By demonstrating that these AKAPs contain a second, distinct binding interface, Stokka’s contributions have been instrumental in explaining how subtle variations in anchoring proteins can direct different PKA isoforms to distinct signaling complexes. Her research has profound implications for understanding diseases caused by aberrant PKA signaling, making her a pivotal figure in the field of signal transduction and cellular regulation.
Research Focus
Key Achievements
Top Papers
- 1