Papers
8
Total Citations
135
H-Index
4
About
Ann Spangler is a radiation oncologist whose research has significantly advanced the field of stereotactic partial breast irradiation (S-PBI) for early-stage breast cancer. Her work centers on refining and validating accelerated partial breast irradiation techniques, particularly through the application of robotic stereotactic radiation systems that offer precise, targeted treatment following lumpectomy. Spangler has been a principal investigator in pioneering phase I dose-escalation trials exploring both 5-fraction and single-fraction S-PBI regimens, work that has attracted considerable attention — her most cited study alone has garnered 66 citations since 2017. These trials have demonstrated promising tolerability and favorable cosmetic outcomes, with her 2021 cosmetic outcomes study providing critical evidence that high-dose stereotactic approaches need not compromise patients' quality of life. Her leadership in multi-institutional collaborations underscores the broader applicability of her findings across diverse clinical settings. Beyond clinical outcomes, Spangler has contributed technical innovations, including an ultrasound-guided fiducial marker placement technique and a prototype volumetric ultrasound tomography image guidance system, both designed to address the inherent challenges of target localization in breast radiation therapy. Her body of work collectively represents a sustained effort to make partial breast irradiation safer, more precise, and more accessible to patients with early-stage disease.
Research Focus
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