Anika M. Jonker
Papers
1
Total Citations
102
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1
About
Anika M. Jonker is a leading figure in chemical biology, whose work has profoundly advanced the study of ubiquitin and ubiquitin-like (Ubl) pathways. Her research centers on developing innovative chemical tools to unravel the complex roles of these post-translational modifications in cellular regulation. Jonker’s most notable contribution is the development of a general chemical ligation approach for synthesizing isopeptide-linked ubiquitin and Ubl conjugates. This methodology, detailed in her highly cited 2011 paper (102 citations), enables the creation of fluorescence polarization assay reagents that directly monitor the activity of deubiquitinating enzymes and Ubl-specific proteases. By providing a robust platform to generate these critical biochemical probes, her work has empowered researchers to dissect signaling mechanisms and identify potential therapeutic targets. Jonker’s elegant synthetic strategies have bridged a crucial gap between chemistry and cell biology, making her a pivotal innovator in the field and a key enabler for countless downstream discoveries in protein homeostasis and disease.
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